摘要
急性心肌梗塞患者肾上腺素诱导血小板聚集性降低,与病情有一定关系,一般两周内恢复;5-羟色胺诱导聚集阳性率及不解聚率均明显高于正常对照组;每日口服100mg阿斯匹林明显抑制5-羟色胺及肾上腺素诱导聚集,但不能完全抑制尿激酶引起的血小板聚集增加;蝮蛇抗栓酶对5-羟色胺诱导聚集有明显抑制作用。
The platelet aggregation was observated in 39 patients with acute myocardial infarction (AMI) and 15 patients with unstable angina (UA). The results showed, 1. platelet aggregation induced by epinephrine (E) both in AMI and UA were lower than that of conlrol group. 2, The positive rate and patterns of platelet aggregation induced by 5-hydroxytryptamine (5-HT) both in AMI and UA had significant difference compared with control group. 3. During the therapy with aspirin (ASA) 100mg daily platelet aggregation induced by E and 5-HT were inhibited in patients with AMI. 4. The platelet activation after intravenous urokinase (UK) seem to be inhibited partly by 100mg ASA ingestion.5. Snake venom anti-thrombus enzyme (SVATE) only inhibited platelet aggregation induced by 5-HT. Therefore, SVATE is a weak drug of inhibiting platelet aggregation.
出处
《基础医学与临床》
CSCD
1993年第1期37-40,共4页
Basic and Clinical Medicine
基金
卫生部基金
关键词
心肌梗塞
血小板聚集
钙离子载体
acute myocardial infarction ( AMI) platelet aggregation calcium ionophore A23187 epinephrine ( E ) 5-bydroxytryptamine ( 5-HT )
