摘要
本研究探讨慢性缺氧过程中大鼠左右心室的代偿情况。结果表明,模拟海拔5000米减压缺氧20天和40天后左右心室功能、重量、肌原纤维蛋白含量和Ca^(2+)-ATPase活性均有不同程度的变化。右室主要以舒缩功能代偿为主,左室由于对氧的需求量大,在缺氧20天时可能以较低的Ca^(2+)-ATPase活性维持其正常的舒缩功能,缺氧40天时左右心室的代偿能力均有所削弱。我们认为左右心室代偿与失代偿状况不能由某一方面的变化定论,必须结合多方面的变化作综合分析。
This experiment was carried out to study the ventricular compensation of rats during chronic hypoxic exposure. The results showed that after chronic hypoxia at simulated an altitude of 5 000 m above sea level for 20 and 40 days respectively, righe and left ventricular functions, weights, myofibrillar protein content and Ca2+-ATPase activity changed by different degrees. The increment of ventricular contraction and dilatation is very significant for right ventricle. However there is no significant change for left ventricular function. At 20 days of chionic hypoxia, left ventricular myofibrillar ATPase activity decreased dramatically in comparison with that of 40 days hypoxia. Ventricular myofibrillar protein contents reduced obviously and ventricular compensation diminished after hypoxia for 40 days.It is then suggested that the compensation of right and left ventricles can not be determined only by certain physiologic or biochemic changes. Combination of physiologic and biochemic changes may present comprehensive evaluation of ventricular compensation status.
出处
《基础医学与临床》
CSCD
1993年第3期33-36,共4页
Basic and Clinical Medicine
关键词
缺氧
心室功能
心室肥厚
hypoxia ventricular function ventricular hypertrophy myofibrillar protein myofibillar ATPaae activity
