摘要
目的:观察纳米羟基磷灰石/聚酰胺(n-HA/PA66)复合人工骨板对羊腭部软组织缺损的引导修复作用。方法:将12只羊分为实验与空白对照两组,于羊硬腭中份做18.0mm×14.0mm矩形黏骨膜缺损和15.0mm×13.0mm矩形骨缺损,实验组在缺损处植入人工骨板封闭骨质缺损,空白对照组不做任何修复。术后通过大体、病理切片观察黏骨膜组织生长情况和新生组织结构。结果:实验组黏骨膜组织沿人工骨表面爬行生长,于6周内完全关闭软组织缺损;空白对照组软硬组织未能自行愈合。结论:n-HA/PA66人工骨板可引导羊腭部黏骨膜沿其生长,自行修复一定大小的软组织缺损,而达到腭部软组织缺损修复重建的目的。
PURPOSE: To evaluate the effect of n-HA/PA66 plate as a guided implant for the regeneration of the soft tissue defects in palatal region of goats. METHODS: 12 goats were divided into experimental group and control group at random. 18.0mm×14.0mm soft tissue defect and 15.0mm×13.0mm hard tissue defect were formed artificially in hard palate. n-HA/PA66 plates were implanted to the defect in the experimental group. The tissue regeneration in the defects was observed and the structure of regenerating tissue was analyzed by histology. RESULTS: The mucoperiosteal tissue in the experimental group regenerated along the n-HA/PA66 plates and the mucoperiosteal defects were closed in 6 weeks. The soft and hard tissues were not closed up in control group in 6 weeks. CONCLUSION: n-HA/PA66 plates can guide the regeneration of mucoperiosteal tissue to close the palatal defects.
出处
《上海口腔医学》
CAS
CSCD
2004年第5期389-392,共4页
Shanghai Journal of Stomatology
基金
国家九五863项目(715-002-0150)
关键词
组织再生
人工骨
纳米生物材料
腭部缺损
Tissue regeneration
Artificial bone
Nanometer
Defect of palate
