摘要
以靛红酸酐、2-氨基醇和马来酸酐为原料合成了一类N-嚼唑啉苯基取代马来酰亚胺衍生物。考察了催化剂种类、原料配比、反应时间和温度等反应条件对酰胺酸环化反应的影响,发现ZnCl2／HMDS二组分体系是比较有效的催化剂,确定了最佳反应条件,产物收率可达到60％以上。应用核磁共振、红外光谱及元素分析等方法对产物进行了表征。
N - [ o - (4 -alkyloxazol -2 - yl) phenyl] maleimides were synthesized from isatoic anhydride, 2-aminoalcohol and maleic anhydride. In the key step of preparation-the cyclodehydration of maleamic acid, various reaction parameters including catalyst, time,and temperature, were examined in detail. The combination of ZnCl2 and hexamethyl disilazane (HMDS) was found to be an efficient catalyst for this reaction. Under optimum conditions, the maleimide - based derivatives bearing bulky oxazoline groups were obtained in yields more than 60% .The resulting compounds were characterized by 1H NMR,FTIR and elemental analysis.
出处
《石油化工》
CAS
CSCD
北大核心
2004年第10期960-963,共4页
Petrochemical Technology
基金
国家自然科学基金项目(20274036)。
关键词
N-取代马来酰亚胺
噁唑啉
脱水环化
<Keyword>N-substituted maleimides
oxazoline
cyclodehydration
