摘要
用示波极谱法测定甲硝唑片,并对其伏安行为进行了研究。结果表明,在pH8的Britton-Robinson缓冲液和1.5mol/L氯化钾溶液组成的底液中,甲硝唑在-0.54V(vs. SCE)出现了一个极谱还原峰,峰电流与其溶液浓度在0.4～1.5mg/L范围内呈良好线性关系(r=0.9975),检测限为1.85×10-6g/L。并用循环伏安法、脉冲极谱法研究了甲硝唑还原峰的电流性质,发现电极反应是完全不可逆的,存在吸附性。
An oscillopolarography was used for determination of metronidazole tablets, and its voltammetricbehavior was investigated. The results showed that a sensitive reduction peak of metronidazole was obtained in the basesolution of B-R buffer solution (pH 8) and 1.5mol/L KCl solution. The peak potential was -0.54V(vs. SCE). The peakcurrent was directly proportional to the metronidazole concentration in the range of 0.4～1.5mg/L(r=0.9975). Thedetection limit was 1.85×10-6g/L. The current property of reduction peak of metronidazole was investigated by the cyclicvoltammetry and pulse polarography. The characteristic irreversible adsorption of the peak was proved.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第11期672-674,共3页
Chinese Journal of Pharmaceuticals
基金
广东省教育厅"千百十工程"优秀人才培养基金(QX02030)
关键词
甲硝唑
示波极谱法
循环伏安法
metronidazole
oscillopolarography
cyclic voltammetry
