摘要
目的 总结原发性结直肠非霍奇金淋巴瘤的诊断和治疗经验。方法 对 33年来收治的 6 8例原发结直肠非霍奇金淋巴瘤的临床资料进行回顾性分析。结果 患者中位年龄 4 6岁 ,男女比例 1 8∶1。腹痛、腹部包块、腹泻、体重下降、便血、恶心呕吐是主要临床表现。肿瘤部位以回盲部最为常见 (49% ,33/ 6 8)。肿瘤最大平均径为 (8 3± 3 6 )cm ,以B细胞来源为主 (94 % ,6 4 / 6 8) ,多为中低度分化 (84 % ,5 7/ 6 8)。ⅠE、ⅡE、ⅢE、ⅣE期患者分别占 4 9%、2 7%、9%、16 %。 6 8例中 4 2例接受根治性手术 ,2 1例为姑息性切除 ,5 9例作了化疗 ,14例接受放射治疗。本组患者累积 1、3、5年生存率分别为 6 3%、4 7%、4 4 %。结论 原发性结直肠的非霍奇金淋巴瘤好发于青壮年男性 ,手术切除和临床分期是影响患者预后的主要因素。
Objective To sum up our experience on the diagnosis and treatment of primary colorectal non-Hodgkin′s lymphoma (PCNHL). Methods Clinical data of 68 PCNHL cases admitted during the past 33 years in Tianjin Cancer Hospital were analyzed retrospectively. Results The median age was 46 years with male to female ratio of 1.8∶1. Main symptoms include abdominal pain, mass, diarrhea, weight loss, bloody stool, nausea-vomiting. The average diameter of the tumor was 8.3 cm. 43% tumors were located in the cecum. Thirty-three patients were in stage ⅠE, 18 in stage ⅡE, 6 in stage ⅢE, 11 in stage ⅣE. Fourty-two patients received radical resection, 26 did palliative resection. 1-, 3- and 5-year survival rate were 63%、 47%、 44%, respectively. Conclusion PCNHL is often seen in young adults with a female preponderence. Surgery and tumor stage were independent prognostic factors.
出处
《中华普通外科杂志》
CSCD
北大核心
2004年第10期605-607,共3页
Chinese Journal of General Surgery
