摘要
目的:观察自行设计构建的甲状腺激素人工神经(PDLLA-T3)桥接大鼠坐骨神经缺损后神经功能的恢复情况。方法:实验设自体神经移植组和不含甲状腺激素的PDLLA材料组作为PDLLA-T3的对照组,大鼠共80只,左侧坐骨神经均为手术组,右侧为正常对照,在2周、1,2个月3个时相点分别进行电生理、肌湿重恢复率和坐骨神经功能指数的测定,电生理测神经的传导速度和潜伏期,2个月时测定肌湿重恢复率。结果:潜伏期和神经传导速度及坐骨神经功能指数(sciaticnervefunc-tionindex,SFI)值在2周时,各组均无显著性差异。1个月后,PDLLA-T3组恢复好于PDLLA组,各组之间差异有显著性意义(P<0.05)。2个月后PDLLA-T3组潜伏期恢复到2.14ms,传导速度29.97m/s,肌湿重恢复率达40.47%,SFI值37.16,均好于PDLLA组(P<0.01)。结论:PDLLA-T3作为神经组织工程材料,能促进大鼠坐骨神经功能的恢复。
AIM: To observe the rehabilitation status of neural function after the injury of sciatic nerve in rats bridged by self designed artificial nerve of thyroid hormone(PDLLA T3). METHODS: There were two groups in this study: nerve autograft group and PDLLA without thyroid hormone group as control group of PDLLA T3, and 80 rats were in the study, all the left sciatics nerves were operation group, and the right sciatic nerves were normal control group.The recovery ratio of electrophysiology including nerve conduction velocity and latent period, the tibialis anterior muscle gravity, sciatic nerve function index(SFI) were detected respectively after 2 weeks,1 month and 2 months, and the recovery ratio of tibialis anterior muscle gravity was detected at 2 months. RESULTS: After 2 weeks, neither nerve conduction velocity and latent period nor SFI was good in recovery, no significant differences were observed in each group. One month later, the recovery of PDLLA T3 group was better than that of PDLLA group, significant difference were found in each group(P< 0.05). Two months later, latent period has recovered to 2.14 ms and nerve conduction velocity reached to 29.97 m/s, tibialis anterior muscle gravity was up to 40.47%, SFI to 37.16, all of them were better than those of PDLLA group(P< 0.01). CONCLUSION: PDLLA T3,a nice tissue engineered nerve,can promote the recovery of the rat sciatic nerve injury.
出处
《中国临床康复》
CSCD
2004年第32期7174-7177,共4页
Chinese Journal of Clinical Rehabilitation
