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术中放疗联合区域动脉灌注治疗局部晚期胰腺癌

IORT and regional chemotherapy in patients with locally advanced pancreatic carcinoma
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摘要 目的 :评价术中放疗联合区域动脉灌注治疗局部晚期胰腺癌的效果。方法 :17例局部晚期胰腺癌减黄手术时行术中放疗(IORT) ,胃网膜右动脉插管行 5 -氟尿嘧啶( 5 FU ) +表阿霉素 (EPI) +丝裂霉素(MMC)方案的区域灌注化疗 ,其中 6例术后行外照射放疗。结果 :疼痛缓解率70 5 9% ( 12 / 17) ,临床受益指数 3 5 2 9%( 6/ 17) ,局部病灶部分缓解 2 3 5 3 % ( 4 / 17)。中位生存 11个月 ,1年生存率 3 5 2 9%( 6/ 17)。结论 :IORT结合区域动脉灌注化疗毒副作用轻微 ,可明显提高临床受益率 。 OBJECTIVE:To evaluate the effect of combination of intraoperative radiotherapy (IORT) and regional chemotherapy in patients with locally advanced pancreatic carcinoma.METHODS:Seventeen patients with pancreas adenocarcinoma were treated with IORT and regional chemotherapy including 5-FU,epirubucin and mitomycin, and 6 cases accepted external radiotherapy postoperatively.RESULTS:35.29%(6/17) of patients were clinical benefit responders,23.53%(4/17) had a partial response.The median survival time was 11 months and the 1-year survival rate 35.29%( 6/17).CONCLUSION:The IORT and regional chemotherapy makes a notable impact on clinical benefit in locally advanced pancreatic carcinoma and leads to a significant prolongation of the survival time without severe side effect.
作者 康华峰 王西京 马红兵 刘小旭 薛兴欢 代志军 纪宗正
机构地区 西安交通大学第二医院肿瘤外科
出处 《肿瘤防治杂志》 CAS 2004年第10期1076-1078,共3页 China Journal of Cancer Prevention and Treatment
关键词 胰腺肿瘤/放射疗法 胰腺肿瘤/外科学 胰腺肿瘤/药物疗法 手术期间 pancreatic neoplasm/radiotherapy pancreatic neoplasm/surgery pancreatic neoplasm/drug therapy intraoperation
分类号 R735.9 [医药卫生—肿瘤]
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参考文献11

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肿瘤防治杂志
2004年 第10期

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