摘要
目的 :探讨用肿瘤标志物的方法对大肠癌进行早期诊断、分级、疗效评估和复发监控。方法 :用化学法和化学发光法分别测定 5 7例大肠癌患者血清中肿瘤特异性生长因子 (TSGF)和CA19 9及CEA ,并对他们在大肠癌中早期诊断、分级 ,疗效评估和复发判断的意义进行分析。结果 :手术治疗前大肠癌Duke’sA、B、C分期患者血清中TS GF平均水平分别为 ( 72 4± 17 6)、( 68 4±14 7)和 ( 5 8 7± 18 2 )U/mL ;血清TSGF、CA19 9和CEA对大肠癌诊断的阳性率分别为 86 0 %、79 9%和 70 2 % ,三者联合应用对大肠癌诊断的阳性率和特异性分别为92 9%和 82 1%。治疗有效的患者血清TSGF逐渐降低。大肠癌复发患者 ,其血清TSGF、CA19 9和CEA均高于参考值。结论 :TSGF对大肠癌早期诊断优于CA19 9和CEA ,三者联合应用对大肠癌的早期诊断。
OBJECTIVE:To study early diagnosis,grade,effect valuation and recurrent valuation in colorectal cancer patients by tumor markers.METHODS:The serum tumor specific growth factors (TSGF),CA19-9 and CEA in 57cases of colorectal cancer were determined by the chemistry measurement and chemiluminescence methods,and their valuations analysed in early diagnosis,grade,effects and recurrence of colorectal cancer patients.RESULTS:The mean values of serum TSGF were 72.4±17.6, 68.4±14.7 and 58.7±18.2 U/mL in Duke’s A, B and C patients pretherapied.The positive rates were 86.0%,79.9% and 70.2% of serum TSGF,CA19-9 and CEA.When using them associated,the diagnostic and specific rates were 89.6% and 90.7% in colorectal cancer.When colorectal cancer patients improved with the effective therapy,the value of serum TSGF gradually decreased.In the relapsed colorectal cancer patients,the values of serum TSGF,CA19-9 and CEA were higher than the cut-off values.CONCLUSIONS:The early diagnostic rate of TSGF is higher than those of CA19-9 and CEA.When using them associated,there is of importance for early diagnosis, effect and recurrent valuations in colorectal cancer patients.
出处
《肿瘤防治杂志》
2004年第10期1064-1066,共3页
China Journal of Cancer Prevention and Treatment
