摘要
目的观察阿莫西林、甲硝唑和胶体次枸橼酸铋联合使用对3种大鼠胃溃疡模型的影响,为临床合理选用药物治疗消化道溃疡提供参考。方法用大鼠做成水浸应激性胃溃疡、幽门结扎型胃溃疡及乙酸烧灼型胃溃疡3种模型,试验组给予阿莫西林(225mg·kg-1)、甲硝唑(112mg·kg-1)和胶体次枸橼酸铋(56mg·kg-1)混合物;阳性对照组给予西咪替丁(112mg·kg-1);阴性对照组给予2%羧甲基纤维素钠(CMCNa)。结果试验组呈剂量依赖性保护大鼠水浸应激性胃溃疡形成,有效剂量为112mg·kg-1;呈剂量依赖性保护大鼠幽门结扎型溃疡形成,有效剂量为56mg·kg-1;呈剂量依赖性促进大鼠乙酸烧灼溃疡的愈合,有效剂量为112mg·kg-1。结论试验组呈剂量依赖性对大鼠水浸应激性胃溃疡显示保护作用;呈剂量依赖性减少大鼠幽门结扎型胃溃疡的程度;呈剂量依赖性促进乙酸烧灼溃疡的愈合,但作用均弱于西咪替丁。
AIM: To study the effects of combination usage of amoxicillin (A), metronidazole (M) and colloidal bismuth subcitrate (B) on gastric ulcer in rats and to provide the clinical reasonable medication reference on peptic ulcer. METHODS: 40 rats were divided into 5 groups (n=8 in each): the test groups with the administration of mixture of A, M and B 225, 112 and 56 mg·kg -1 , respectively;the positive control group with the administration of cimetidine 112 mg·kg -1 and the negative control group with the administration of 2% CMC Na. Two thirds of rats in each group were given drugs before being made the gastric ulcer animal models induced by stress and pyloric ligation, and the other one third of rats in each group were given drugs after being made the gastric ulcer models induced by acetic acid injury. RESULTS: The mixture prevented the formation of gastric ulcer induced by stress and pyloric ligation, and healed the gastric ulcer induced by acetic acid injury at the dosage of 112, 56 and 56 mg·kg -1 ,respectively. CONCLUSION: The mixture can dose dependently protect the gastric ulcer induced by stress, reduce the degree of gastric ulcer induced by pylorus ligation, and advance the healing rate of gastric ulcer induced by acetic acid injury, but its effect is lower than that of cimetidine.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第10期1165-1167,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
阿莫西林
甲硝唑
胶体次枸橼酸铋
西咪替丁
胃溃疡
amoxicillin
metronidazole
colloidal bismuth subcitrate
cimetidine
gastric ulcer
