摘要
目的 :研究抑癌基因 PTEN在乳腺癌中的表达并探讨其临床意义。方法 :应用免疫组织化学方法检测92例乳腺癌以及 18例癌旁正常组织中 PTEN表达并分析其与临床病理及预后的相关性。结果 :乳腺癌组织中 PTEN高表达率为 5 4 .3% (5 0 / 92 ) ,明显低于癌旁正常组织 (P<0 .0 1)。 PTEN表达与淋巴结转移、临床分期、组织学分级以及雌激素受体相关 (P<0 .0 5 )。 PTEN高表达的乳腺癌术后 5 a无病生存率明显高于阴性表达者 (P<0 .0 5 )。结论 :PTEN表达与乳腺癌发生、发展及预后密切相关。提示检测抑癌基因
Objective To study the expression of PTEN and its clinicopathological significance in breast cancer.Methods Archival breast carcinomas (n=92), normal breast epithelia ( n=18) were an alyzed for PTEN expression by immunohistochemistry using specific antibody. Results PTEN protein expression was high in 50(54.3 %) of 92 cases in b reast carcinomas, which was significantly different from the expression in norma l breast tissles(P<0.01). PTEN expression level was correlated w ith histological grade, lymphnode metastasis, TNM stage(P<0.05 o r P<0.01). The 5-year DFS of the high-expression group was was significantly higher than the low-expression group in breast cancer(P <0.05).Conclusion PTEN protein expression correlates with the carcinogenesis and progression of breast cancer. PTEN may be a useful marker fo r reflecting tumor malignant behavior and estimating prognosis of breast cancer.
出处
《实用医技杂志》
2004年第10B期2114-2116,共3页
Journal of Practical Medical Techniques
