摘要
目的 比较糖尿病肾病 (DN)患者治疗前后血管内皮生长因子 (VEGF)、血管紧张素Ⅱ (ATⅡ )等含量的变化。方法 用放射免疫法测定正常对照组及糖尿病 (DM )和DN患者血浆VEGF、ATⅡ的含量。结果 DN组和DM组血浆VEGF和ATⅡ浓度明显高于对照组 (P <0 0 1) ;治疗后VEGF、ATⅡ含量明显低于治疗前。
Objective To investigate the contents of plasma vascular endothelial growth factor(VEGF),angiotensin Ⅱ(ATⅡ),albumin excretion rate(AER) before therapy and after treatment in the patients with diabetes mellitus(DM) and diabetic nephropathy(DN).Methods Before therapy and after treatment,the levels of plasma VEGF and ATⅡ were measured by radioimmunoassary,AER and the other markers were measured in our center laboratory.Results The plasma levels of VEGF and ATⅡ were significantly increased in the patients with DM and DN compared with those in the controls(P<0.01).The plasma levels of VEGF and ATⅡ after treatment were significantly lower than those before therapy.Conclusion VEGF may be important to the development of DN.
出处
《中国基层医药》
CAS
2004年第11期1294-1295,共2页
Chinese Journal of Primary Medicine and Pharmacy
