摘要
目的 利用胃癌细胞株 ,观察脱氧氟尿苷 (FUDR)与常用化疗药物的相互作用。方法 利用MTT法测定FUDR与其它四种化疗药的单药和联合用药对胃癌细胞株的抑制率。结果 单种药物化疗敏感性顺序 :GEM >OXA >MMC >FUDR >5FU >CDDP ;联合用药的敏感性顺序 :CDDP +FUDR >MMC +FUDR >GEM +FUDR >OXA +FUDR。除GEM +FUDR组CI >1外 ,其它三组的CI <1。除MMC +FUDR组DRI<1外 ,其他各组DRI均 >1。三组三种药物联合用药的敏感性相似 ,CI均 <1,DRI均 >1。三种药物联用明显优于两种药物的联合用药。结论 FUDR与MMC或铂类化疗药联用对胃癌细胞株有显著的抑制作用 ,与OXA联用最为理想 。
Objective To evaluate the influence of doxifluridire(FUDR) on common anti tumor drugs in chemotherapy for gastric cancer cell line in vitro.Methods MTT assay was employed to determine the cytotoxicity(inhibition rate) of four common anti tumor drugs,with or without 5 FUDR,against gastric cancer cell line.Results When used alone,the sensitivity sequence of these drugs against gastric cancer cell line was GEM>OXA>MMC>FUDR>5 FU>CDDP.When combined with 5 FUDR,drug sensitivity sequence was CDDP+FUDR>MMC+FUDR>OXA+FUDR>GEM+FUDR.DRI in all groups is above 1 except in MMC+FUDR group.Similarly,MMC+OXA+5FUDR>MMC+CDDP+FUDR>MMC+GEM+FUDR.DRI in three drug groups is better than in two drug groups.Conclusion FUDR combined with MMC or platina analogs can definitely inhibit the growth of gastric cancer cells.Combination of FUDR and OXA has favorable effect,but has negative effect if combined with GEM.Combined use of three drugs has more advantages.
出处
《中国基层医药》
CAS
2004年第11期1308-1309,共2页
Chinese Journal of Primary Medicine and Pharmacy
