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热休克蛋白60的研究进展 被引量：22

Recent advances in heat shock protein 60
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摘要 The family of HSP60 belongs to heat shock proteins with highly species conservatism and some important biologic functions. It can help other proteins for their assembling, folding and translocating, and plays a role in protecting cells against injuries and other types of stress. In addition, HSP60 is frequently recognized by the immune system as predominant antigens during infections and the progression of certain autoimmune diseases and might provide a novel strategy for the development of immunotherapeutics. This review focuses on distribution, molecular chaperone mechanism, function and gene expression regulation of HSP60. [ The family of HSP60 belongs to heat shock proteins with highly species conservatism and some important biologic functions. It can help other proteins for their assembling, folding and translocating, and plays a role in protecting cells against injuries and other types of stress. In addition, HSP60 is frequently recognized by the immune system as predominant antigens during infections and the progression of certain autoimmune diseases and might provide a novel strategy for the development of immunotherapeutics. This review focuses on distribution, molecular chaperone mechanism, function and gene expression regulation of HSP60. [
作者 龚兴国 于红
机构地区 浙江大学生命科学学院
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2004年第11期2151-2154,共4页 Chinese Journal of Pathophysiology
关键词 监控蛋白60 免疫疗法 Chaperonin 60 Immunotherapy
分类号 R363 [医药卫生—病理学]
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参考文献27

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二级参考文献4

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中国病理生理杂志
2004年 第11期

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