摘要
目的 研究枪击噪音对大鼠液体食物胃肠传输的影响 ,并通过测定大鼠血浆胃肠激素浓度的变化探讨枪击噪音致胃肠传输功能紊乱发生的机制。方法 32只SD大鼠随机分组 ,以模拟 5 6式冲锋枪射击时产生的噪音为施加因素 ,分别给予不同强度的噪音刺激 ,采用炭粉推进法观察不同强度的声刺激对大鼠液体食物胃肠传输的影响 ,通过放射免疫法测定血浆胃肠激素浓度 ,包括血浆胃动素(MLT)、生长抑素 (SS)、P物质 (SP)、血管活性肠肽(VIP)。结果 当枪击噪音强度在 80dB以下时 ,大鼠胃肠传输液体食物速度为轻度抑制 ,与对照组比较差异无统计学意义 (P >0 0 5 ) ;噪音强度达 80dB时 ,血浆SS、SP、VIP浓度均较对照组升高 ,差异有统计学意义 (P <0 0 5或P <0 0 1) ;当枪击噪音达到 12 0dB时 ,大鼠胃肠传输液体食物速度较对照组明显加快 (P <0 0 5 ) ,同时血浆MLT、SS、SP的浓度也发生了明显的变化 (P <0 0 1)。结论 当枪击噪音在一定强度范围内时 ,大鼠血浆胃肠激素浓度已发生改变 ,但其胃肠对液体食物的传输功能仍保持在相对正常的范围 ;当枪击噪音超过一定强度时 ,大鼠血浆胃肠激素浓度发生了明显的变化 ,其胃肠对液体食物的传输功能发生紊乱。
Objective To study the effect of the sound produced by firing a firearm on gastrointestinal transit of liquid food and its mechanism. Methods Thirty-two SD rats were randomly divided into control group and stimulating groups. Different intensity of sound produced by firing sub-machine guns was used as impacting factor. The ratio of carbon suspension transmission was measured to determine the effect of sound on gastrointestinal transit of liquid food. Plasma levels of polypeptide hormones were measured by radioimmunoassay. Results When the sound was less than 80dB in intensity, the gastrointestinal transit was slightly inhibited(P>0.05), but serum levels of, SS, SP and VIP were higher than those of control group (P<0.05 or P>05). When the intensity reached 120dB, gastrointestinal transit was accelerated significantly(P<0.05), and serum levels of gastrointestinal hormones were remarkably increased too(P<0.01). Conclusion When firing sound reached a certain intensity, it would result in marked changes in serum levels of gastrointestinal hormones, together with a disorder in gastrointestinal transit of liquid food in rats.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2004年第11期991-992,共2页
Medical Journal of Chinese People's Liberation Army
关键词
噪声
胃肠通过试验
胃肠激素类
noise
gastrointestinal transit
gastrointestinal hormones
