期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

11β羟类固醇脱氢酶1型与代谢综合征 被引量：2

下载PDF
导出
摘要 糖皮质激素可诱导胰岛素抵抗 ,11β羟类固醇脱氢酶 1型 (11βHSD1)催化无活性的可的松转化为有活性的氢化可的松 ,调节局部糖皮质激素水平。 11βHSD1促进脂肪细胞增生、肥大 ,导致中心性肥胖 ;可增加肝糖输出 ,导致胰岛素敏感性下降 ,产生糖尿病 ;动物实验表明 11βHSD1基因高表达可导致高血压。 11βHSD1将成为代谢综合征干预的又一靶点。
作者 章晓燕 贾伟平
机构地区 上海交通大学附属第六人民医院
出处 《国外医学（内分泌学分册）》 2004年第6期383-386,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 代谢综合征 类固醇 糖皮质激素 醇脱氢酶 肥大 中心性 靶点 肝糖 高表达 脂肪细胞
分类号 R589 [医药卫生—内分泌]
  • 相关文献

参考文献20

  • 1Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab, 2003
  • 2Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase .type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab,2003
  • 3Rask E, Walker BR, Soderberg S, et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose llbetahydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab,2002,87: 3330-3336.
  • 4Anderws RC, Rooyackers O, Walker BR, et al. Effects of the 11β-hydroxysteroid dehydrogenase gene inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab, 2003,88:285-291.
  • 5Draper N, Echwald SM, Lavery GG, et al. Association studies between microsatellite markers within the gene encoding human 11β-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism. J Clin Endocrinol Me
  • 6Paulmyer-Lacroix O, Boullu S, Olver C, et al. Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab, 2002,87: 2701-2705.
  • 7Bjomtorp P, Rosmond R. The metabolic syndrome-a neuroendocrine disorder? Br J Nutr, 2000, 83 ( Suppl 1 ): S49-S57.
  • 8Jeremy MS,Tomlinson ND,Joanna M,et al. Absence of cushingoid phenotype in a patient with cushing' s disease due to defective cortisone to cortisol conversion. J Clin Endocrinol Metab,2002,87:57-62.
  • 9Gabriely I, Ma XH, Yang XM, et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes,2002,51:2951-2958.
  • 10Livingstrone DE, Jones GC, Smith K, et al. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zuker rats. Endocrinology, 2000,141: 560-563.

同被引文献29

引证文献2

二级引证文献5

国外医学（内分泌学分册）
2004年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部