摘要
目的研究葛根素在大鼠体内的药物动力学过程以及乳糖酸红霉素对葛根素在大鼠体内药物动力学过程的影响。方法对大鼠分别单独静注葛根素溶液 ,联合静注葛根素和不同剂量的乳糖酸红霉素溶液 ;采用高效液相色谱法测定葛根素在大鼠体内的血药浓度 ;用 3P97药动学程序计算其药物动力学参数。结果葛根素在大鼠体内的药物动力学过程呈双隔室开放模型 ;乳糖酸红霉素在低剂量时 (0 2 5g·L-1和 2 5 0g·L-1)对葛根素的药动学过程无显著性影响 (P >0 0 5 ) ,但在高剂量时 (12 5 0 g·L-1)有显著性影响 (P <0 0 1)。结论葛根素与乳糖酸红霉素合用时 ,乳糖酸在一定质量浓度内 ,二者可联合用药 ;在较高质量浓度 (12 5 0g·L-1)时会显著抑制葛根素从大鼠体内的消除 ;
Objective To investigate the effect of erythromycin lactobionate on the pharmacokinetics of puerain in rats.Methods Puerarin with or without erythromycin lactobionate was administered intravenously to rats,respectively.The concentration of puerarin in serum was determined by HPLC,and the pharmacokinetic parameters were obtained by the pharmacokinetic software named 3P97.Results The pharmacokinetics of puerarin conformed to a two-compartment open model.No significant difference was found between the control and (0.25 g·L^(-1)),(2.50 g·L^(-1)) erythromycin lactobionate combined groups (P>0.05),and there was significant difference between the control and 12.50 g·L^(-1) erythromycin lactobionate combined group (P<0.01).When the dose of erythromycin lactobionate was below (2.5 g·L^(-1)),it had no effect on the pharmacokinetics of puerarin.But puerarin elimination was inhibited by erythromycin lactobionate when the dose was more than (12.50 g·L^(-1)).Conclusions It is necessary to change the therapeutic dose of puerarin when the drug is coadministered with erythromycin lactobionate.
出处
《沈阳药科大学学报》
CAS
CSCD
2004年第6期412-415,共4页
Journal of Shenyang Pharmaceutical University
