摘要
目的观察阿司匹林及细菌脂多糖对大鼠应激所致的行为性抑郁影响.方法将72只SD雄性大鼠随机分为对照组和应激组.应激组大鼠在16 d内接受不同类型的应激,制备应激性抑郁症模型.采用开场试验检测大鼠的行为性抑郁,用甲基噻唑基四唑比色法测定淋巴细胞转化. 结果慢性应激大鼠从第7～14天出现总活动路程、总活动时间和中区活动时间减少,呈现明显的行为性抑郁.腹腔注射细菌脂多糖(100 μg/kg)可加重应激引起的行为性抑郁,并加强应激大鼠血清对正常淋巴细胞转化的抑制作用,导致正常大鼠的总活动路程显著缩短.阿司匹林(50 mg/kg)对正常大鼠无显著性影响,但可减轻大鼠的行为性抑郁和应激大鼠血清对正常淋巴细胞转化的抑制作用.结论腹腔注射细菌脂多糖加重应激大鼠的行为性抑郁,阿司匹林可减轻大鼠的行为性抑郁.
Objective To investigate the effects of aspirin, an anti-inflammatory drug, on chronic stress induced behavioral depression and serum immune activity in rats. Methods All 72 male SD rats were randomly divided into stress and control group. The rats in stress group were given 8 kinds of mild stressors in 16 days to induce behavioral depression. Behavioral depression was examined with Open Field test, and lymphocyte proliferation detected with methyl thiazolyl tetrazoliom. Results Rats in stress group appeared behavioral depression, including decreases of total moving distance, motion time and movement in central area. Intraperitoneal injection of lipopolysaccharide (LPS, 100 μg/kg) increased stress-induced behavioral depression including time in motion, moving distance and time in central area in Open Field test. LPS also increased the inhibition of serum on lymphocyte proliferation. By contraries, aspirin (50 mg/kg) reversed the behavioral depression induced by chronic stress in rats, and relieved the inhibition of serum from depressant rat on lymphocyte proliferation. Conclusion Aspirin alleviates behavioral depression induced by chronic stress, which may be via the demotion of brain proinflammatory cytokines.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2004年第4期236-240,共5页
Chinese Journal of Psychiatry
基金
国家自然科学基金资助项目(30370518)解放军回国人员科研启动基金资助项目(01H033)
