摘要
目的 :探讨 p5 3、bcl- 2蛋白在鼻 NK/ T淋巴瘤表达 ,及其与细胞凋亡和预后的关系。方法 :应用原位末端标记技术和免疫组织化学 (SP法 ) ,检测 2 4例鼻 NK/ T淋巴瘤中细胞凋亡和 p5 3、bcl- 2蛋白的表达水平。结果 :p5 3、bcl- 2蛋白在鼻 NK/ T淋巴瘤表达的阳性率分别为 6 2 .5 % (15 / 2 4 )和 16 .7% (4 / 2 4 ) ;细胞凋亡与 p5 3蛋白明显负相关 (P<0 .0 0 5 ) ,与 bcl- 2蛋白表达无关 (P>0 .5 )。 p5 3表达和细胞凋亡与患者的预后无关 (P>0 .0 5 )。结论 :鼻 NK/ T淋巴瘤细胞凋亡调控及其发病机制是受多基因调节的复杂过程 ;突变型 p5 3是抑制该肿瘤细胞凋亡的一个重要因子。但瘤细胞凋亡和 p5
Objective:To explore the expressions of p53,bcl-2 genes and their relationships with cell apoptosis and prognosis of nasal NK/T cell lymphomas.Methods:24 nasal NK/T cell lymphoma samples were enrolled. Immunohistochemical staining and apoptosis by TUNEL were carried out in all cases.Results:The p53 and bcl-2 positive rates were 62.5%(15/24) and 16.7%(4/24), respectively. The expression of p53,but not bcl-2, was inversely correlated with apoptotic index among 24 nasal NK/T cell lymphomas. No significant correlation among the expression of p53,apoptosis and the prognosis was found.Conclusions:The pahthogenesis and the regulation of apoptosis in nasal NK/T cell lymphoma were complex process,in which p53 mutant might be a key factor of inhibiting apoptosis of tumor cells.However no significant correlation among apoptosis ,p53 and prognosis was found in this group of cases.
出处
《中国误诊学杂志》
CAS
2004年第5期670-672,共3页
Chinese Journal of Misdiagnostics
基金
贵州省教委基金资助项目 (NO.1 999- 4 77)
