摘要
合成并表征了一种L型Boc酪氨酸修饰的自由卟啉(LBocTyrTAPP)及其锌卟啉配合物Zn(LBocTyr)TAPP.通过紫外-可见光谱滴定法,研究了手性锌卟啉配合物与四对对映异构的手性氨基酸酯客体在CHCI3中的分子识别行为.实验结果表明,在分子识别的过程中,缔合常数顺序均为D型略大于L型,且按K(PheOMe)>K(AIaOMe)>K(ValOMe)>K(LeuOMe)的顺序依次减小.同时,利用园二色光谱进一步阐述手性分子识别过程.此外,采用分子力学方法搜索了主客体体系的最低能量构象,从理论上对实验本质进行较深入的探讨.
One kind of novel zinc prophyrin complex modified by L-BocTyrosine was synthesized and characterized. Molecular recognitions of four pairs of amino acid esters by the chiral zinc porphyrin have been investigated with UV-Vis spectral method. The results show that association constants of the recognition process are all in the order of K-D > K-L, following the order K(PheOMe) > K(AIaOMe) > K(ValOMe) > K(LeuOMe). Circular dichroism spectra have been used to explain chiral molecular recognition. In addition, the conformations with minimal energy of host and host-guest molecular systems were sought by molecular dynamics method. Experimental essence was more deeply discussed by theoretical calculation.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2004年第21期2165-2170,共6页
Acta Chimica Sinica
基金
国家自然科学基金(Nos.20171024
20271030)
天津市自然科学基金(No.023604011)
教育部留学回国人员科研基金资助项目.
