摘要
目的 :评价尿脱落细胞中survivin的表达和尿nmp2 2的表达对诊断尿路上皮肿瘤的价值。 方法 :对4 8例尿路上皮肿瘤患者 ,在行膀胱镜检查或手术前留新鲜尿液分别行尿脱落细胞survivin、尿nmp2 2和尿脱落细胞检查 ,并分别比较各方法的敏感性、特异性。结果 :尿路上皮肿瘤患者尿脱落细胞涂片中survivin表达 4 8例中4 6例阳性 ,尿NMP2 2有 38例阳性 ,而尿脱落细胞学仅 15例阳性 ,survivin的敏感性高于nmp2 2及脱落细胞学 (P <0 .0 5及P <0 .0 1)。三者的特异性分别为 10 0 %、90 %和 10 0 % ,差异无统计学意义。结论 :检测尿脱落细胞中survivin的表达方法简单无创敏感性、特异性高对诊断尿路上皮肿瘤的价值优于尿nmp2 2。
Objective:To assess the diagnostic value of survivin and nmp22 in the detection of transitional cell carcinoma.Methods:Patients of transitional cell carcinoma were asked to have survivin in urinary exfoliative cell, urine nmp22 and cytological examination before cystoscopy or operation.Results:Among 48 patients, there are 46 positive of survivin examination in urinary exfoliative cell, and 38 positive of urine NMP22, and only 15 positive in cytological examination.The sensitivity of survivin was significantly better than nmp22 and urinary cytology. The specificity of survivin, nmp22 and urinary cytology was 100%,90% and 100%,respectively.Conclusions:This study indicates that survivin in urinary exfoliative cell is a simple, noninvasive, sensitive and specific marker for the detection of transitional cell carcinoma, and its value is higher than nmp22.
出处
《临床泌尿外科杂志》
2004年第11期680-682,共3页
Journal of Clinical Urology
