摘要
目的 :探讨充血性心力衰竭 (CHF)患者肾素、血管紧张素和醛固酮活性的变化。方法 :采用放免法测定收缩压 (pSB) <13.33kPa的CHF患者 (A组 ,2 8例 ) ,pSB>13.33kPa的CHF患者 (B组 ,32例 )及健康人 (对照组 ,2 5例 )血浆肾素活性 (PRA)、血管紧张素Ⅱ (AngⅡ )及醛固酮 (ALD)水平。结果 :A组及B组血浆PRA、AngⅡ和ALD均明显高于对照组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;A组血清钠、pSB及脉压 /pSB显著低于对照组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;A组血浆PAR、AngⅡ和ALD高于B组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;A组血清钠、pSB及脉压 /pSP显著低于B组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;CHF患者脉压 /pSB与血浆AngⅡ及ALD呈负相关 (r=- 0 .4 6 2 ,P <0 .0 1;r=- 0 .4 4 3,P <0 .0 1)。结论 :CHF患者体内肾素 -血管紧张素 -醛固酮系统活性增高 ,且pSB<13.33kPa者高于pSB>13.
Aim: To investigate the changes of renin,angiotensin,and aldosterone activity in patients with congestive heart failure(CHF) Methods: A total of 60 patients were divided into two groups according to their systolic blood pressure(p SB):①patients with p SB<13.33 kPa (group A,n=28); ②patients with p SB>.33 kPa (group B,n=32).Normal control group included 25 health people. Plasmal levels of renin, angiotensin,and aldosterone (PRA,AngⅡ and ALD) were measured by radio-immunity assay(RIA). Results: Plasma levels of PRA, AngⅡ,and ALD in group A and B were significantly higher than those of control group(P<0.05 or 0.01),especially in group A (compared with group B, P< 0.05 or 0.01).Group A had lower serum sodium, p SB,and pulse pressure/systolic pressure compared with group B (P< 0.05 or 0.01). There was a negative relationship between the pulse pressure/systolic pressure and the AngⅡ and ALD levels(r=-0.462,P<0.01; r=-0.443,P<0.01)in CHF patients. Conclusion: Renin,angiotensin,and aldosterone activity increase in CHF patients, especially in the patients with lower p SB less than 13.33 kPa.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2004年第6期982-984,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省自然科学基金资助项目 0 3 2 44 10 13 2
