摘要
目的探讨妊娠期糖尿病视网膜病变的发病规律、进展因素和防治措施。方法随机检测32例DR孕妇、32例NDR孕妇和32例正常孕妇的视力、屈光、眼底、血糖、糖基化血红蛋白、果糖胺和羊水情况。结果(1)妊娠期糖尿病的发病率为61%;(2)妊娠期糖尿病视网膜病变的发病率为144%;(3)妊娠期糖尿病视网膜病变的进展率为3125%;(4)妊娠中期,DR孕妇组血中糖基化血红蛋白和果糖胺水平明显高于正常孕妇组(P<005);(5)妊娠晚期,DR孕妇和NDR孕妇组血中糖基化血红蛋白和果糖胺水平明显高于正常孕妇组(P<005);(6)妊娠晚期,DR孕妇组羊水过多的患病率明显高于正常孕妇组(P<001)。结论妊娠会促进糖尿病孕妇的视网膜病变加重,可能与血中糖基化血红蛋白和果糖胺水平增高有关。积极观察和治疗,能够减少糖尿病孕妇的视力损害,避免提前终止妊娠给胎儿带来的不利影响。
Objective To investigate the disease law,progress agent,prevention and cure measure of Diabetic Retinopathy(DR)during pregnancy.Methods The vision,refraction,fundus,blood sugar,glycohemoglobin(GHb),Fructosamine(FRUCT)and amniotic fluid have been detected in 32 diabetic retinopathy gravidas,32 no-diabetic retinopathy gravidas and 32 normal gravidas.Results (1)The morbidity of gestational diabetic is 6 1%;(2)The morbidity of gestational diabetic retinopathy is 1 44%;(3)The progress rate of gestational diabetic retinopathy is 31 25%;(4)The mean levels of GHb and Fructosamine in DR gravidas were significantly higher than those in normal gravidas during middle pregnancy.;(5)The mean levels of GHb and Fructosamine in diabetic retinopathy gravidas and no-diabetic retinopathy gravidas were significantly higher than those in normal gravidas during late pregnancy;(6)The morbidity of excessive amniotic fluid in Diabetic Retinopathy gravidas was significantly higher than that in normal gravida.Conclusions The pregnancy accelerates retinopathy in diabetic gravide,it can relation to the high level of GHb and Fructosamine.By active observation and treatment,it can to reduce the vision lesion of diabetic gravide and to avoid premature termination pregnancy.
出处
《中国实用眼科杂志》
CSCD
北大核心
2004年第11期909-912,共4页
Chinese Journal of Practical Ophthalmology
基金
广东省医学科学技术研究基金(A2001569)
