摘要
目的 观察间苯三酚复合剂在产程进展中的作用。方法 选择正常初产妇、宫口开大2～ 3cm伴宫颈水肿者 97例 ,随机分为间苯三酚复合剂组 (4 6例 ) ,待宫口开大 2～ 3cm后 ,给予间苯三酚复合剂 80mg静脉推注 ;阿托品组 (5 1例 ) ,待宫口开大 2～ 3cm后 ,给予阿托品 0 5mg宫颈注射。观察两组产妇用药后的产程变化及围产结局。结果 (1)用药至宫口开全的时间 ,间苯三酚复合剂组平均为 (3 1± 0 3)h ,阿托品组平均为 (4 4± 0 4 )h ,两组比较 ,差异有极显著性 (P <0 0 1)。 (2 )用药后 2h的宫颈水肿消失率 ,间苯三酚复合剂组为 95 6 % ,阿托品组为 90 2 % ,两组比较 ,差异无显著性 (P >0 0 5 ) ;较用药前平均宫口开大 ,间苯三酚复合剂组为 (4 3± 0 2 )cm ,阿托品组为 (2 5± 0 3)cm ,两组比较 ,差异有极显著性 (P <0 0 1)。 (3)间苯三酚复合剂组产妇及胎儿未发现明显副作用 ;阿托品组用药后 15～ 30min ,8例产妇诉口干 ,2 2例产妇心率每分钟增加 10～ 15次 ,同时伴胎心率基线升高 ,约 6 0min后恢复。 (4 )阴道分娩率 ,间苯三酚复合剂组为 95 6 % ,阿托品组为 90 2 % ,两组比较 ,差异无显著性 (P >0 0 5 )。 (5 )产时羊水情况、新生儿窒息情况及新生儿体重在两组间比较 ,差异均无显著性
Objective To observe the effects of Spasfon on improving dilatation of cervix and promoting the progression of labor. Methods Ninety seven normal primiparae with cervical edema were randomly divided into Spasfon group (group A, n=46) and atropine group (group B, n=51) when the cervix dilated 2-3 cm. Group A was given 80 mg of Spasfon intravenously, and group B was injected atropine 0.5 mg into the cervix. Results (1) The mean time period from drug administration to full dilation of the cervix was (3.1±0.3)h in group A, and (4.4±0.4) h in group B (P<0.01). (2)The disappearance ratio of cervical edema 2 h after drug administration in group A was 95.6%, while in group B it was 90.2% (P>0.05); the mean dilatation of cervix between the 2 hours in group A was (4.3±0.2) cm, while in group B it was (2.5±0.3 ) cm (P<0.01). (3)There were no obvious side effects in group A. While eight women in group B complained of thirst and 22 women had increased heart rate accompanied with elevated baseline FHR, which all recovered in about 60 minutes. (4)Vaginal delivery rate in group A was 95.7%, and 90.2% in group B (P>0.05). (5) There was no statistically significant difference in the color of amniotic fluid, suffocation state and weight of the newborns between the two groups(P>0.05). (6) There was no statistically significant difference in postpartum hemorrhage between the two groups, either(P>0.05). Conclusion Spasfon can effectively improve cervical dilatation during labor and it is well tolerated by both mother and newborn.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2004年第9期606-608,共3页
Chinese Journal of Obstetrics and Gynecology
