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子宫颈储备细胞增生与CD44v5在其细胞中的表达 被引量:8

PROLIFERATION OF CERVICAL RESERVE CELLS AND IMMUNOHISTOCHEMICAL STUDY OF CD44v5
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摘要 目的 研究宫颈储备细胞增生时的形态表现及其免疫组织化学特点 ,为探讨癌变机理提供依据。 方法 观察 2 38例宫颈良性疾病中储备细胞增生的发生率及其多种形态表现 ;用免疫组织化学法检测 5 4个病例中CD4 4v5的表达情况。 结果与结论  1 在多种宫颈良性疾病中储备细胞普遍呈增生状态 ;2 增生细胞的形态可分为 4型 :大细胞型、小细胞型、透明细胞型及梭形细胞型 ;3 CD4 4v5在各型储备细胞中 10 0 %均呈强阳性表达。多种宫颈良性疾病中存在储备细胞增生 ;储备细胞可能来源于间质。 Objective Cervical reserve cells are the maternal cells of cervical neoplasia. It's proliferation and origin were studied. Methods The pathological morphology of cervical reserve cell proliferating was observed by light microscopy in 238 cases of cervical benign diseases; Immunohistochemical technology of CD44v5 was used to inspect the expression of cervical reserve cells in 54 cases. Results and Conclusion 1.Reserve cell proliferation was common in most cases of cervical benign diseases and it was originated from stroma; 2 The proliferating reserve cells were composed of four types:large cells, small cells, clear cells and spindle cells; 3The expression of CD44v5 in reserve cells showed 100% strongly positive. The cells proliferation was common in begin diseases of cervix; Reserve cells possibly were originated from stroma.
出处 《解剖学报》 CAS CSCD 北大核心 2004年第5期551-554,共4页 Acta Anatomica Sinica
关键词 子宫颈 储备细胞 CD44V5 Cervix Reserve cells CD44v5
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参考文献3

  • 1Wilson EB.The Cell in Development and Heredity[M]. New York:The Macmillan Co, 1986: 3-7.
  • 2Alex F, Barbara W. Anotomg and Histology of Cervix [ M ]. In: Kurman R J, ed. Blanstein's Pathology of the Female Genital Tract. 3rd ed. Berlin: Springer Verlag, 1987:141 - 157.
  • 3Emad M. Ibrahim M, Anthony D. CD44 is a marker of endcervical neoplasis [J]. Int J Gyneol Pathol, 1999,18(2): 101-108.

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