摘要
灯盏花素(breviscapine)是菊科植物短葶飞蓬(Erigeron breviscapus(vant.)Hand-Mazz)中提取的黄酮类有效成分.临床多用于治疗脑梗死、脑血栓、脑出血等.将药物制成脂质体,能帮助药物进入脑部,提高治疗指数[1].灯盏花素水溶性较差,直接溶于注射用水有一定困难,将其制成脂质体可以解决其难溶问题,提高药物稳定性及载药量,同时提高药物的靶向性及疗效.包封率是脂质体质量评定的重要指标,本实验建立了灯盏花素纳米脂质体包封率的测定方法,该法操作简单、可行、准确性较好.
Aim To determine the entrapment efficiency of breviscapine nanoliposomes. Methods Retrodialysis method was used to determine the entrapment efficiency of breviscapine nanoliposomes. The drug recovery and the sample recovery were considered to verify the feasibility of the method. Results The drug recovery was ( 99. 6 ± 0. 6 ) % . The sample recovery was ( 99. 9 ±0. 8 ) % . The entrapment efficiency of breviscapine nanoliposomes was (75. 3 ±2. 3 ) % . Conclusion The method used in this study is simple, applicable and accurate for determination of the entrapment efficiency of breviscapine nanoliposomes.
出处
《药学学报》
CAS
CSCD
北大核心
2004年第9期755-757,共3页
Acta Pharmaceutica Sinica
关键词
灯盏花素
纳米脂质体
包封率
反透析法
breviscapine
nanoliposome
entrapment efficiency
retrodialysis
