摘要
目的 探讨山丘型疫区日本血吸虫再感染的有关危险因素。方法 选取一山丘型疫区,随访观察居民吡喹酮普治后疫水接触及血吸虫再感染状况,对可能影响血吸虫再感染的有关因素进行非条件logistic回归分析。结果 多因素非条件logistic回归分析结果显示再感染与下列因素有关:化疗前每克粪便虫卵数(OR=2.066,95％CI:1.173～3.639),性别(OR=4.260,95％CI:1.275～14.235),4～10月份疫水接触平均指数B(OR=1.138,95％CI:1.045～1.240),性别与4～10月疫水接触平均指数B间的交互作用(OR=0.875,95％CI:0.817-0.982)。结论 性别、化疗前感染度、疫水接触的持续时间及暴露面积与再感染的发生有关,其中性别与疫水接触之间尚存在弱的拮抗作用。
Objective To explore the risk factors of Schistosoma japonicum reinfection after chemotherapy in a hilly endemic area. Methods In a hilly endemic area of S. japonica, data on contact to contaminated water and the rates of reinfection after mass praziquantel treatment were collected from residents who participated in a prospective cohort study on S. japonica. An unconditional logistic regression analysis was performed to identify the risk factors associated with the reinfection of S. japonicum. Results Logistic regression analysis data showed that three factors were associated with S. japonicum reinfection: eggs per gram stool (EPG) prior to chemotherapy ( OR=2. 066,95 % CI:1. 173-3. 639), gender ( OR=4. 260,95 % CI:1. 275-14. 235) and average degree of exposure (Index B) from April to October (OR=1. 138,95 % CI : 1. 045- 1. 240). Interaction between gender and average exposure Index B from April to October was identified ( OR=0.875,95% CI:0.817-0.982). Conclusion Eggs per gram stool (EPG) prior to chemotherapy, level of exposure to infected water and gender were risk factors for reinfection with S.japonicum after chemotherapy. In addition, there appeared an antagonism between gender and level of exposure to infected water.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2004年第8期691-694,共4页
Chinese Journal of Epidemiology
关键词
日本血吸虫再感染
危险因素
流行病学
吡喹酮普
治疗
Schistosoma japonicum
Chemotherapy
Risk factors
Unconditional logistic regression analysis
