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幽门螺杆菌感染儿童HLA-DQA1的免疫遗传学特征 被引量:3

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摘要 目的:了解昆明汉族儿童中幽门螺杆菌(H pylori)感染率及其HLA-DQA1免疫遗传学特征. 方法:用胶体金标免疫渗滤法检测153名6-14岁的学生血H pylori-IgG抗体.并用聚合酶链反应-序列特异性引物(PCR-SSP)技术对以血清学试验及13C尿素呼气试验确诊的34例H pylori感染儿童及37例无H pylori感染儿童进行HLA—DQA1基因分型. 结果:昆明儿童H pylori感染率为34.5%,其HLA-DQA1*0103 等位基因频率明显高于无H pylori感染儿童(29.41% vs 9.46%,P=0.002,Pc=0.028,OR=3.988,95%CI: 1.562-10.180);而H pylori感染儿童HLA-DQA1*0302等位基因频率低于无H pylori感染儿童(19.12% vs 33.78%, P=0.049,OR=0.463,95%CI:0.214-1.003),但经等位基因多项比较校正,差异消失(Pc=0.686). 结论:昆明汉族儿童H pylori感染率较高.他们在HLA- DQA1位点上与无H pylori感染儿童存在免疫遗传学差异,HLA-DQA1*0103基因可能是H pylori感染的易感基因;而DQA1*0302基因则是否具有免疫抵抗作用,需要进一步研究.
出处 《世界华人消化杂志》 CAS 2004年第7期1735-1737,共3页 World Chinese Journal of Digestology
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参考文献15

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二级参考文献2

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