摘要
目的 :观察当归与黄药子合用时 ,当归对黄药子的减毒作用及不同比例当归对黄药子毒性的影响。并探讨其减毒机制。方法 :对比黄药子组、黄药子当归 1∶1、 1∶2、 2∶1组小鼠在给药 2 1天后肝脏生化指标、病理及肝微粒体中SOD、GST活性。结果 :当归各比例组对黄药子引起的GTP、GOT、ALP、TBil升高及病理变化的改变有明显抑制作用 ;黄药子当归 1∶2组作用最好。肝微粒体中SOD、GST活性增强。结论 :当归各比例组对黄药子毒性均有抑制作用 ,其中黄药子当归 1∶2组作用最好。其减毒机制与对抗肝微粒体生物氧化酶和药物代谢酶活性抑制有关。
Objective:To observe the detoxification action of Chinese angelica root to Dioscorea bulbifera L and the influence of Chinese angelica root in different ratios to the toxicity of Dioscorea bulbifera L, and to investigate the detoxification principle of Chinese angelica root to Dioscorea bulbifera L. Methods: The biochemical indexes, pathology results and GST, SOD activity in liver microsome at the time of 21 days after the administration of medicine in Dioscorea bulbifera L group and Dioscorea bulbifera L and Chinese angelica root groups were observed, and the ratios of Dioscorea bulbifera L to Chinese angelica root were 1∶1,1∶2, 2∶1 respectively.Results: The groups of Chinese angelica root in different ratios to Dioscorea bulbifera L all have obvious inhibition action to the increases of GPT, ALP, TBil and pathology changes caused by Dioscorea bulbifera L, and the inhibition action was best when the ratio of Dioscorea bulbifera L and Chinese angelica root was 1∶2. At the same time, GST, GST-PX and SOD activity were raised. Conclusion: The groups of Chinese angelica root in different ratios to Dioscorea bulbifera L all have inhibition action to the toxicity of Dioscorea bulbifera L, and the inhibition action is best in the group which the ratio of Dioscorea bulbifera L and Chinese angelica root is 1∶2. The principle of the detoxification action of Chinese angelica root is relevant to its antagonism to the activity of biologic oxidation enzyme and medicine metabolizability enzyme in liver mitochondria.
出处
《中西医结合肝病杂志》
CAS
2004年第4期216-218,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
国家中医药管理局专项基金资助项目(No:02-03zp29)
关键词
当归
黄药子
减毒作用
中药
药理
Dioscorea bulbifera L
Liver Toxicity
Chinese Angelica Root
Detoxification
Principle
