摘要
目的 通过动物实验 ,以了解硅凝胶乳房假体包膜中胶原组织学特点。方法 30只大白兔 ,每只大白兔背部两侧肌层下随机各置入 10ml硅凝胶假体 1个。 3周、1、2、3、6、12个月时分别将包膜和假体完整地取出 ,在光学显微镜下测量包膜厚度 ,取包膜样本做成石蜡切片 ,进行HE染色、James染色、维多利亚蓝、丽春红复合染色和天狼猩红染色 ,光学显微镜下观察比较包膜特点 ,其余包膜样本进行胶原分型和含量测定。结果 ⑴假体组织学特点 :大致可分为两层 ,包膜外层为疏松结缔组织 ,内层为致密结缔组织。包膜厚度在 3个月前逐渐增加 (P <0 .0 1) ;置入时间越长 ,假体包膜胶原成分越多、细胞成分越少 ,包膜越厚 (P <0 .0 1) ;3个月后 ,趋于稳定 (P >0 .0 5 )。⑵包膜胶原总量在 3个月前逐渐增高(P <0 .0 1) ;3个月后趋于稳定 (P >0 .0 5 )。⑶ 3个月前 ,包膜中胶原纤维最多 ,网状纤维次之 ,弹力纤维最少甚至无 ;,3个月后趋于稳定。⑷ 3个月前 ,包膜Ⅲ型胶原有减少趋势 ,Ⅰ型胶原有增多趋势 ;3个月后 ,均趋于稳定。结论 假体包膜在组织学上与瘢痕类似 。
Objective To study the histologic characteristics of the capsule of breast implant. Methods Four miniprostheses were seperatelly implanted in four positions beneath the panniculus carnosus muscle in 30 rabbits. After 3 weeks, 1, 2, 3, 4, 6 and 12 months, capsular histology examination and the assay of capsular collagen content and type were performed. Results ⑴ Capsule was divided into two layers: the inner layer was dense and the outer loose connective tissues. Collagen component was more, cellular component was less and capsule was thicker (P<0.01) before 3 months. There were no significant changes after 3 months (P>0.05). ⑵ Capsular collagen content increased gradually in 3 months (P<0.01), and there were no significant change after 3 months (P>0.05). ⑶Collagen fibers were the most component, reticular fibers were second and elastic fibers were least. After 3 months, elastic fibers decreased, and collagen and reticular fibers became full layer gradually. ⑷ Capsular collagen type I in the capsule was gradually increased and type III decreased before 3 months. There were no significant changes after 3 months. Conclusions Histology of the implant capsule is similar to that of scar and the result of wound healing around implant.
出处
《中华医学美学美容杂志》
2004年第4期222-225,共4页
Chinese Journal of Medical Aesthetics and Cosmetology
