摘要
目的 :了解孕妇 TORCH感染的危害程度 ,临床预防并干预先天性心脏病 ( CHD)患儿的出生。方法 :应用 Ig M捕获免疫技术对健康首胎及 2胎孕妇进行抗人巨细胞 Ig M血清流行病学监测。结果 :首胎孕妇 732 1例 Ig M阳性 880例 ,阳性率为 12 .0 2 % ;2胎 5 2 3例中阳性 93例 ,阳性率 17.80 % ;2 34例有先天性心脏病家族史的孕妇 Ig M阳性率 2 2 .2 2 % ,两者之间差异有高度显著性 ( P<0 .0 1)。随访发现 ,在这些孕妇中其 CHD的出生率分别是 0 .76 % ,2 .6 5 % ,7.6 0 %。结论 :母亲 TORCH感染 ,特别是 CMV感染 ,CMV Ig M抗体阳性与 CHD密切相关 ,开展孕妇
Objective:To know harm degree of pregnant women's TORCH infection, to prevent and interfere the birth of infants with congenital heart disease (CHD). Methods:Serum anti-human cytomegalovirus IgM in healthy women for first and second time was monitored epidemiologically with IgM catching immunoassay. Results: Of 7321 cases for first time, there were 880 cases of positive IgM (12.02%); of 523 cases for second time, there were 93 cases of positive IgM (17.03%). 234 pregnant women with CHD family history were positive IgM (22.22%), there were significant difference between two groups ( P <0.01). By following-up, rate of birth with CHD in these pregnant women was 0.76%, 2.65% and 7.60% respectively.Conclusion: If mother with TORCH infection, especially CMV infection, there was tight correlation between CMV IgM positive antibodies and CHD. Thus, monitoring epidemiological serum CMV in pregnant women has important eugenic significance.
出处
《中国妇幼保健》
CAS
2004年第9期44-45,共2页
Maternal and Child Health Care of China
