摘要
目的 探讨结直肠腺癌组织中细胞胀亡与血管内皮生长因子 (VEGF)的关系。方法 应用透射电镜观察 5 0例结直肠腺癌组织中的细胞胀亡情况 ,并应用免疫组织化学S P法检测VEGF表达情况 ,分析两者的相关性。结果 结直肠癌组织中存在细胞胀亡 ;结直肠癌组织细胞胀亡指数 (OI)随分化程度降低而降低 (P <0 .0 5 ) ;淋巴结转移组OI明显低于无淋巴结转移组 (P<0 .0 1) ;OI与Dukes分期无关 (P >0 .0 5 ) ;结直肠癌组织中VEGF的阳性表达率为 5 2 .0 % ( 2 6/5 0 ) ,与肿瘤的分化程度、Dukes分期、淋巴结转移密切相关 (P <0 .0 1,P <0 .0 5 ,P <0 .0 1) ,而癌旁组织中无VEGF阳性表达 ,两组比较有非常显著性差异 (P <0 .0 1)。OI与VEGF的阳性表达率呈负相关 (γ =-0 .73 0 ,P <0 .0 1)。
Objective To investigate the interrelationship between oncosis and the expression of VEGF in colorectal adenocarcinoma.Methods By using transmission electron microscope and immunohistochemical technique SP method,oncosis and VEGF expression in 50 cases of colorectal adenocarcinoma were determined,and the interrelationship between them was studied.Results Oncosis existed in colorectal carcinoma.Oncosis index(OI) in tissues of colorectal carcinoma decreased with the decrease of differentiation grades(P<0.05);OI was lower in the cases with lymph node metastasis than those without(P<0.01).OI was not related to Dukes stage(P>0.05).The positive rate of VEGF was 52.0%(26/50) in colorectal adenocarcinoma,and it was closely correlated with tumor differentiation grades,Dukes stage,lymph-node metastasis(P<0.01,P<0.05,P<0.01),and VEGF was negative in para-carcinoma tissue,the difference was significant between the two groups(P<0.01).OI was negatively correlated with the expression of VEGF(γ=-0.730,P<0.01).Conclusion Oncosis and the expression of VEGF has a significant correlation to the biological behavior in colorectal adenocarcinoma.
出处
《实用癌症杂志》
2004年第3期262-264,共3页
The Practical Journal of Cancer
