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肿瘤坏死因子相关的凋亡诱导配体及其在骨髓增生异常综合征和白血病方面的研究进展

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摘要 肿瘤坏死因子相关的凋亡诱导配体(TRAIL)是TNF超家族新成员,它可以选择性诱导肿瘤 细胞凋亡,而对正常细胞无毒性作用,这种特性使其可能在肿瘤治疗中发挥巨大潜力。本文就TRAIL及其 在骨髓增生异常综合征和白血病方面的研究进展作一综述。
作者 冯丽华 李大启 崔为发
机构地区 潍坊医学院血液学教研室
出处 《国外医学（输血及血液学分册）》 2004年第6期535-538,共4页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
关键词 肿瘤坏死因子相关的凋亡诱导配体 骨髓增生异常综合征 白血病 细胞凋亡 白血病
分类号 R551 [医药卫生—血液循环系统疾病] R733.7 [医药卫生—肿瘤]
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参考文献28

  • 1Zang DY, Goodwin RG, Loken MR, et al. Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis. Blood, 2001,98(10): 3058-3065.
  • 2Secchiero P, Gonelli A, Mirandola P, et al. Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway. Blood, 2002,100(7) :2421-2429.
  • 3Benesch M, Platzbecker U, Ward J, et al. Expression of FLIP (Long) and FLIP (Short) in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome:correlation with apoptosis. Leukemia, 2003,17 (12): 2460-2466.
  • 4Platzbecker U, Ward JL, Deeg HJ. Chelerythrin activates caspase-8, downregulates FLIP long and short, and overcomes resistance to tumour necrosis factor-related apoptosis-inducing ligand in KG1a cells. Br J Haematol,2003,122(3):489-497.
  • 5Ghaffari S, Jagani Z, Kitidis C, et al. Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor. Proc Natl Acad Sci U S A,2003,100(11) :6523-6528.
  • 6Secchiero P, Milani D, Gonelli A, et al. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells. J Leukoc Biol, 2003,74(2): 223-232.
  • 7Nicholson DW. From bench to clinic with apoptosis-based therapeutic agents. Nature, 2000,407(6805): 810-816.
  • 8Wiley SR, Schooley K, Smolak P J, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 1995,3 (6): 673-682.
  • 9Plasilova M, Zivny J, Jelinek J, et al. TRAIL (Apo2L)suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia, 2002,16 (1): 67-73.
  • 10Lee NS, Cheong HJ, Kim SJ, et al. Ex vivo purging of leukemia cells using tumor-necrosis factor-related apoptosis-inducing ligand in hematopoietic stem cell transplantation. Leukemia, 2003, 17(7):1375-1383.
国外医学（输血及血液学分册）
2004年 第6期

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