摘要
目的评估拉米夫定与а-2b干扰素在儿童乙型肝炎患者中的疗效。方法实验分两组:INF组给30名乙型肝炎的儿童皮下注射а-2bINF,300万U/次,每周3次,共12个月。INF+LAM组给30名患儿拉米夫定3mg/kg(最大100mg)+а-2b干扰素治疗12个月。结果治疗结束时,HBeAg的转阴率分别为30%和67%(P<0.05);HBV-DNA转阴率分别40%和73%,(P<0.05);ALT的复常率为67%和87%;TSB的复常率为70%和90%(P<0.05)。结论联合治疗组HBV-DNA转阴率、ALT恢复率及HBeAg的转阴率均高于单用干扰素组。
Objective To evaluate the efficacy of α-2b interferon combined with lamivudine on children with chronic hepatitis B.Methods 30 children with CHB received INF alphα-2b (300万U/d),3 times a week for 12 months.Other 30 children with CHB were given α-2b INF +LAM (3mg·kg-1·d-1) 3 times a week for 12 months.Results At the end of treatment,the ALT and TSB normalization rate were 67%and 70%in group INF,respectively.87%,90%in group INF+LAM (P<0.05).There were significant difference in the HBV-DNA seroconversion rate and HBeAg negative rate between two groups (P<0.05).Conclusion INF+LAM therapy for chronic hepatitis B is more effective than INF monotherapy in inhibiting viral replication and getting ALT normalization.
出处
《中国现代医药杂志》
2004年第5期19-20,共2页
Modern Medicine Journal of China
