摘要
合成了2,6 二 O 戊基 β 环糊精键合硅胶固定相(PCDS)。利用傅里叶红外光谱、X射线光电子能谱、莫氏(Molisch)试验颜色反应对其进行了表征。以邻苯二甲酸二甲酯、甲苯和菲为测试溶质,评价该键合固定相的色谱性能,并考察了该固定相对一些位置异构体的色谱分离效果,讨论了可能的分离机理。
In order to improve the chiral separation capability of the conventional β-cyclodextrin bonded-silica gel stationary phase, 2,6-di-O-pentyl-β-cyclodextrin bonded stationary phase(PCDS) was prepared via a long spacer. The resulted bonded-silica stationary phase was characterized by three methods, namely Fourier transform infrared, Molisch color reaction, X-ray optical electrical energy spectrogram. The chromatographic performances of PCDS were investigated by using liquid chromatography with toluene, dimethyl phthalate, and phenanthrene as solutes, and their retention mechanism was investigated and discussed. The results show that the introduction of pentyl to β-cyclodextrin leads to enhancement of the retention of the solutes. The chiral separation capability of the new bonded-silica stationary phase was evaluated by using liquid chromatography with some chiral drugs. Some of the enantiomers such as chlorphenamine maleate and bupropion hydrochloride were separated by heptakis ((2,6-di-O-pentyl))-β-cyclodextrin bonded silica stationary.
出处
《色谱》
CAS
CSCD
北大核心
2004年第6期630-633,共4页
Chinese Journal of Chromatography
关键词
高效液相色谱
2
6-二-O-戊基-β-环糊精
键合硅胶
固定相
手性分离
high performance liquid chromatography
2,6-di-O-pentyl-β-cyclodextrin
bonded silica gel
stationary phase
enantiomer separation
