Efficient Synthesis of the Cl- C7 Fragment of Didemnaketal A

Efficient Synthesis of the Cl- C7 Fragment of Didemnaketal A

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摘要 The stereoselective synthesis of the C1-C7 fragment (3R,4S,6R)-3,4-di[(tert-butyl-dimethylsilyl)oxy]-7-hydroxy-6-methylheptan-2-one, which is the crucial intermediate for synthesis of the HIV-1 protease inhibitive didemnaketals, was developed via 12 steps from the natural (+)-pulegone. The stereoselective synthesis of the C1-C7 fragment (3R,4S,6R)-3,4-di[(tert-butyl-dimethylsilyl)oxy]-7-hydroxy-6-methylheptan-2-one, which is the crucial intermediate for synthesis of the HIV-1 protease inhibitive didemnaketals, was developed via 12 steps from the natural (+)-pulegone.

作者 XueQiangLI XueZhiZHAO PeiNianLIU YongQiangTU

机构地区 DepartmentofChemistryandStateKeyLaboratoryofAppliedOrganicChemistry

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第7期757-758,共2页 中国化学快报（英文版）

关键词 Didemnaketals stereoselective synthesis intramolecular chiral induction Mitsunobu reaction. Didemnaketals, stereoselective synthesis, intramolecular chiral induction, Mitsunobu reaction.

分类号 O629.1 [理学—有机化学]

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Chinese Chemical Letters

2004年第7期

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Efficient Synthesis of the Cl- C7 Fragment of Didemnaketal A

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