摘要
用无针注射器注射醋酸去炎松治疗了412例烧伤后增生性瘢痕,总有效率99.5％。其作用机制可能是:①抑制成纤维细胞胶原蛋白的合成;②成纤维细胞退行性改变,减少胶原纤维生成;③内皮细胞损害,减少瘢痕血供,利于胶原酶破坏胶原纤维。
412 cases of postburn hyperplastic scars were treated by intradermal triamcinolone acetonide which was introduced by a jet injector. The effective rate was 99.5%, Histopathological and electron microscopic observations were made in 5 cases. The mechanism of therapeutic effect is as follows: (1) inhibition of synthesis collagen; (2) decreased formation of collagenous fiber due to regressive changes of fibrobalsts; (3) reduced blood supply in scars due to damages to endothelial cells, facilitating the destruction of collagenous fibers by collagenase.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1993年第6期430-432,共3页
Medical Journal of Chinese People's Liberation Army
关键词
醋酸去炎松
瘢痕
烧伤
Triamcinolone acetonide
Hyperplastic scar
Burn
