摘要
目的 :了解我院急、慢性腹泻病人的菌群分布及耐药性特征 ,为临床用药提供依据。方法 :应用回顾性调查分析的方法 ,对我院近 4年腹泻病人大便中分离的 2 6 6株病原菌进行统计并对常见细菌耐药率进行分析。结果 :急性腹泻病人最常见的是福氏志贺菌 ,食物中毒引起的腹泻最常见的是沙门氏菌和弗氏枸橼杆菌 ,慢性腹泻病人最常见的是弗氏枸橼酸杆菌 ,其次是变形杆菌、亚利桑那菌和白色念珠菌。分离菌株中耐药性以氨苄西林、头孢唑啉的耐药率最高 ,达 (33%～ 92 % ) ,对亚胺培南、第四代头孢菌素较敏感 ,敏感率在 90 %以上。弗氏枸橼酸杆菌产AmpC酸占 33%。结论 :腹泻病人的病原菌都有不同程度的耐药性 ,进行常规的耐药性监测 。
Objective:To investigate bacterial distribution and drug resistance characteristics of clinical isolates from acute or chronical diarrhea patients in our hospital.Methods:266 pathogen isloates from stool of diarrhea patients was evaluated retrospectively.Results:The most common pathogen bacteria in acute diarrhea patinet is Shigella flexneri,while Citrobacter freundli,Proteus species,cholerasuls subsp and Candids albieans are the leading four important pathogen that result in chronic diarrhea.Bacteria food poisoning was usually caused by Salmonella species or Citrobacter freundli.Of all 266 isolates,(33% to 92%) are resistant to Ampicillin and Cefazolin,In contrast,susceptibility rate of these isolates to Imipenem and the fourth generatio cephalosporins was more than 90%.The AmpC producing strains accounts for 33% in Citrobacter freundli.Conclusion:Most isolates from diarrhea patients have different levels of drug resistance,which should be monitored routinely.And it is important to select antibiotics according to the drug sensitivity test.
出处
《华西医学》
CAS
2004年第3期419-420,共2页
West China Medical Journal
