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大鼠左室肥厚心肌PPARα信号通路失活及其意义 被引量：1

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摘要 目的 :观察压力超负荷左室肥厚心肌过氧化物酶体增殖剂活化受体α(PPARα)mRNA和蛋白的表达变化 ,探讨PPARα信号通路失活与左室肥厚心肌能量底物转换的关系。方法 :检测大鼠腹主动脉缩窄术后 2周、4周和 8周血流动力学参数、心室重塑指标、血清和心肌游离脂肪酸的含量及PPARαmRNA和蛋白的表达变化。结果 :术后 2周左室已出现肥厚 ,伴有PPARαmRNA表达下调 ;术后 8周PPARα蛋白水平开始下调 :随着肥厚程度的增加 ,血清和心肌游离脂肪酸蓄积增加 ,左室心肌PPARαmRNA和蛋白的表达进行性下调。结论 :病理性肥厚心肌PPARα活性下调与能量底物的利用变化相一致 。
作者 胡琴 李隆贵 吴立荣 方颖 刘兴德
机构地区 贵阳医学院附属医院心内科 重庆第三军医大学新桥医院心内科
出处 《心肺血管病杂志》 CAS 2004年第3期166-169,共4页 Journal of Cardiovascular and Pulmonary Diseases
关键词 大鼠 左室肥厚 PPARΑ 信号通路失活 血流动力学
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献13

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共引文献17

同被引文献21

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引证文献1

二级引证文献2

心肺血管病杂志
2004年 第3期

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