摘要
目的:探讨尿白胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)在链球菌感染后肾小球肾炎发病中的作用。方法:对26例患儿和50名健康儿童的尿用ELISA技术分别检测IL-6和TNF-α的含量。结果:肾炎组IL-6含量(12.81±9.29mg/L)较对照组(2.36±1.26mg/L)高,差异有显著性(P<0.01);肾炎组TNF-α含量(101.06±59.15mg/L)较对照组(32.85±11.38mg/L)高,差异亦有显著性(P<0.01)。结论:尿IL-6和TNF-α含量的增加,在链球菌感染后肾小球肾炎的发病中起着重要作用,其含量的变化可以作为监测本病发生发展及预后的参考指标之一。
Objective: The aim of this study was to probe into the influence of IL-6 and TNF-a in urine which might be the pathogenic factors of post streptococcal glomerulonephritis (PSGN). Methods: The content of IL-6 and TNF-a in urine was detected with ELISA in 26 patients and 50 healthy children. Results .-The content of IL-6 in PSGN group(12.8 ± 9.29mg/L)was higher than which in control group(2.36± 1.26mg/L)and had significant difference (P <0.01);The content of TNF-α in PSGN group(101.06 ± 59.15mg/L) was also higher than which in control group (32.85 ± 11.38mg/L) and had significant difference(P < 0.01) too. Conclusion: The increase of content of IL-6 and TNF-α in urine plays an important role in PSGN and the change of content could be one of the reference index detecting the development and prognsis of PSGN.
出处
《中国中西医结合肾病杂志》
2000年第2期95-96,共2页
Chinese Journal of Integrated Traditional and Western Nephrology
