摘要
目的 复制大鼠实验性胃溃疡模型 ,研究胃舒康胶囊对大鼠实验性胃溃疡的治疗作用并探讨其作用机制。方法 ①将胃溃疡模型大鼠分为对照组和实验组。实验组以胃舒康混悬液 ( 7.5g/kg、3 .75g/kg)灌胃 ,对照组分别以西咪替丁 ( 1 0 0 0mg/kg)和生理盐水灌胃 ,各组均每天 1次。连续 1 2d后解剖取胃 ,观察胃舒康胶囊对胃溃疡的治疗作用。②大鼠 5 0只 ,分组、用药同前 ,每天 1次 ,共 7d。末次灌胃后结扎幽门 ,术后 2h取胃收集胃液。结果 胃舒康混悬液对实验性胃溃疡有明显的抑制作用 ;对胃液量及游离酸有抑制作用。结论 胃舒康胶囊对实验性胃溃疡有治疗作用 ,其治疗作用可能与抑制胃酸分泌、降低胃酸度的作用有关。
Objective To reconstruct t he ex perimental gastric model of rats, study the therapeutic function of Weishukang capsules to the experimental gastric ulcer of rats and discuss its functional me chanism. Method ①To divide the gastric ulcer model of rats into control group and exper imental group. The rats of experimental group were given ig.by Weishukang suspen sion (7.5 g/kg, 3.75 g/kg)once a day, the rats of control group were given ig.by cimetidine suspension(100mg/kg) and physiological saline respectively onc e a day. The above actions were to be done for 12 days successively. The stomach es of rats were taken out by vivisection 12 days later to observe the therapeuti c function of Weishukang capsules to gastric ulcer. ②Take 50 rats, give the same medicine as the above once a day,7 days altogether. Ligature pylori of the rats a fter the last ig,take out the stomachs so as to collect gastric juice 2 hours af ter the operation. Results Weishukang suspension had an evi dent restrainable function to the experi mental gastric ulcer;and it also has a restrainable function to both the amount of gastric juice and free acid. Conclusion Weishukang capsu le has a therapeutic function to the experimental gastric ulcer and the function may be related to t he function of the restrain of gastric secretion as well as the reduction of gas tric acid.
出处
《河南科技大学学报（医学版）》
2004年第3期165-166,共2页
Journal of Henan University of Science & Technology:Medical Science
基金
河南省自然科学基金项目 (991 1 70 644)
关键词
胃舒康胶囊
大鼠
实验
胃溃疡
治疗
Weishukang
gastric ulcer model
therapeutic function
