摘要
目的 探讨中药三七总苷对急性坏死性胰腺炎 (ANP)大鼠的治疗作用及肠道细菌易位的影响。方法 逆行胆胰管注射 5 %牛磺胆酸钠溶液制成ANP模型。 90只大鼠随机分为假手术组、ANP组和治疗组 ,每组各 30只。每组 10只观察 1周生存率 ;另每组各 2 0只观察术后不同时相血清淀粉酶及胰腺、肝、脾、肺和肠系膜淋巴结细菌培养情况及病理组织学变化。结果 治疗组的存活率明显高于ANP组 ,术后 12h及 2 4h血清淀粉酶明显低于ANP组 ,治疗组胰腺、肝、脾、肺及肠系膜淋巴结细菌培养阳性率亦低于ANP组 ,治疗组病理损害明显轻于ANP组。
Objective To study the effects of Chinese traditional medicine Sanqizonggan on bacterial translocation in rats with acute necrotizing pancreatitis (ANP).Methods The rat model of ANP was established by retrograde bile-pancreatic duct injection of 5% sodium taurocholate. All rats were randomly divided into three groups: the sham-operation group( n =30), ANP group( n =30), and ANP+Chinese traditional medicine group ( n =30). The serum amylase was detected at 0 h,12 h,24 h, and one-week survival rate and pancreatic histological changes were observed in three groups, and the bacterial translocation from intestinal lumen was examined. Results The survival rate of the group treated with Chinese traditional medicine was significantly higher than that of the ANP group. The rate of bacterial translocation in the treated group significantly decreased. Conclusion The Chinese traditional medicine Sanqizonggan can promote gastrointestinal movement, protect intestinal mucosa and reduce bacterial translocation from intestinal lumen.
出处
《中国普外基础与临床杂志》
CAS
2004年第6期505-507,共3页
Chinese Journal of Bases and Clinics In General Surgery
