摘要
目的:观察宁心膏透皮给药治疗冠心病心绞痛(AP)的临床疗效及其对氧自由基的影响。方法:100例AP患者随机分为常规西药加宁心膏组(治疗组)50例和常规西药加凡士林软膏组(对照组)50例,观察临床疗效.并测定疗程前后血清超氧化物歧化酶(SOD)和过氧化脂质(LPO)。结果:治疗组和对照组的AP疗效总有效率及心电图疗效总有效率分别是92%、63.0%和78%、37.8%(P<0.05或P<0.01);两组均可提高SOD并降低LPO,但治疗组较对照组为优(P均<0.05)。结论:宁心膏透皮给药能提高中西医结合治疗AP的疗效,提示该药能透皮吸收,扩张冠状动脉,改善心肌缺血及抗氧自由基。
Objective: To observe clinical therapeutic effect of skin-penetrating administration ot Ningxin Plaster on angina pectoris of coronary heart disease (AP)and its effects on free radicals. Methods: 100 cases of AP were randomly divided into a treatment group treated by routine western medicine plus Ningxin Plaster (n=50)and a control group treated by routine western medicine plus vaseline(n=50). Their therapeutic effects were observed. and serum SOD activity and LPO level were determined before and after treatment. Results:The total effective rates for AP and for ECG in the two groups were 92. 0%. 63. 0%, and 78. 0%, 37. 8%, respectively (P<0. 05 or P<0. 01): SOD increased and LPO decreased in the two groups, but the treatment group was superior to the control group (P<0. 05). Conclusion: Skin-penetrating administration of Ningxin Plaster can increase the therapeutic effect of integrated treatment of Chinese and western medicine. indicating that the drug can be absorbed by penetrating the skin, dilate coronary artery, improve ischemic mayocardium and has the action of anti-free radicals.
出处
《中医杂志》
CSCD
北大核心
2004年第11期834-835,851,共3页
Journal of Traditional Chinese Medicine
基金
江苏省中医药管理局资助课题(9931)
