摘要
目的探讨特发性真性性早熟(简称性早熟)女童骨骼发育异常的规律及滋阴泻火中药(简称中药)治疗的效果。方法对不同青春发育水平的性早熟女童进行骨龄、骨矿含量(BMC)、骨密度(BD)及血清骨钙素(BGP)、胰岛素样生长因子1(IGF1)、胰岛素样生长因子结合蛋白3(IGFBP3)含量的测定,将各项指标与正常同龄儿作比较,并与病情严重程度作相关分析,以探讨患儿骨骼发育异常的规律。其中38例患儿经中药治疗病情缓解后观察其治疗效果。结果(1)117例性早熟患儿骨龄均比正常同龄儿明显提前(P<005);BMC、BD和血清BGP、IGF1含量均明显高于正常同龄儿(P<005),且骨龄提前程度、BMC、BD、血清IGF1含量增高程度与性早熟病情严重程度均呈正相关(P<005)。(2)经中药治疗病情缓解后38例患儿骨龄提前明显减轻,BMC、BD、血清BGP和IGF1含量均显著下降(P<005)。结论(1)性早熟女童的骨骼发育加速、成熟提前,且病情越重,其加速、提前的程度越严重。(2)中药具有明显减慢患儿骨骼发育,延缓骨骼成熟的作用。
To explore the pattern of abnormal skeletal development in girls with idiopathic precocious puberty (IPP) and the therapeutic effect of Chinese herbs for nourishing yin and purging fire (CH). Methods Measurement of bone age, bone mineral content (BMC) and bone density (BD) were performed and levels of serum gla protein (BGP), insulin like growth factor 1 (IGF 1) and insulin like growth factor binding protein 3 (IGFBP3) were determined in girls with IPP at various stages of pubertal development. Data were compared with those collected from matched girls, and the correlativity between various parameters and the extent of the disease were analyzed to explore the pattern. Thirty eight girls out of them were treated with CH and the therapeutic effect was observed. ResultsThe bone age of the IPP girls was ahead of time obviously (P<0 05), levels of BMC, BD and serum BGP, IGF 1 were significantly higher than the levels in the healthy girls of matched age (P<0 05). And the degree of these changes were markedly positive correlated with the severity of disease (P<0 05). After being remitted with CH treatment, the advanced bone age was apparently alleviated, and above mentioned abnormal criteria were lowered significantly (P<0 05). ConclusionThe skeletal development of the girls with IPP was accelerated and the skeletal maturity were ahead of time, the more serious the condition of disease, the more obvious the acceleration and the advanced bone age. CH could decelerate skeletal development and delay the skeletal maturity of IPP patients.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2004年第11期979-982,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
卫生部科研基金(No.98-1-172)
关键词
特发性真性性早熟
骨骼发育
规律
滋阴泻火中药
胰岛素样生长因子1
儿童
idiopathic precocious puberty
regulation of skeletal development
Chinese herbs for nourishing yin and purging fire
