摘要
多巴胺在胃肠道分布广泛,与胃肠道的运动、分泌等功能密切相关。动物实验和人体研究均证实多巴胺具有明显的胃肠道黏膜保护作用。其机制可能是通过作用于多巴胺受体而影响胃的分泌、运动和黏膜血流。不同的受体亚型作用相异。人类的胃十二指肠黏膜中以多巴胺D4亚型的mRNA表达为多。D4的激动剂喹吡罗对MPTP溃疡模型大鼠胃肠道黏膜的保护作用显著强于阻滞剂氯氮平。多巴胺受体亚型功能的深入研究,将为开发新型胃肠道黏膜保护剂提供依据。
Dopamine distributes widely in the gastrointestinal (GI) tract,and is associated with the secretary and motility function of GI tract. Animal experiments and human studies showed that dopamine has strong GI mucosa protection. Dopamine affects the GI tract functions via dopamine receptors (DR) possibly. The different subtypes of DR show variable effectiveness. D4 is the dominant subtype expressing in human gastro-duodenum. D4 agonist quinpirole could resist the effectiveness of MPTP-induced mucosa injury in rat,while the antagonist clozapine had no such effect. Understanding the function of DR in GI tract is very important for developing new drugs of GI tract mucosa protection.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2004年第11期981-983,共3页
Chinese Journal of New Drugs
关键词
多巴胺
黏膜保护
喹吡罗
氯氮平
dopamine
mucosa protection
quinpirole
clozapine
