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DIAGNOSTIC VALUE OF DENSITY GRADIENT CENTRIFU-GATION FOR EXFOLIATIVE TUMOR CELLS IN MALIG-NANT PLEURAL EFFUSIONS

DIAGNOSTIC VALUE OF DENSITY GRADIENT CENTRIFU-GATION FOR EXFOLIATIVE TUMOR CELLS IN MALIG-NANT PLEURAL EFFUSIONS
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摘要 Objective To find out a specific method for diagnosis of malignant pleural effusions (MPEs)with higher sensitivity and practicality. Methods The diagnosis of MPEs were made using density gradient cen-trifugation(DGC) , smear cytologic examination( SCE) and pleural needle biopsy (PNB). Comparisons between these results and those of benign pleural effusions were also made. Results The positive rates of DGC,SCE and PNB for diagnosing MPEs were 94. 3% ,62. 9% and 44. 6% , respectively, and the positive rate of SCE combined with PNB for diagnosing MPEs was 73. 2%. The positive rate of the exfoliative tumor cells ( ETCs ) by DGC was much higher than that of SCE or/and PNB with no false-positive. Conclusion The ETCs isolated by DGC from the MPEs is quite specific for the diagnosis of malignant tumors with higher sensitivity and practicality in clinico-patho-logical practice. To find out a specific method for diagnosis of malignant pleural effusions ( MPEs )with higher sensitivity and practicality. Methods The diagnosis of MPEs were made using density gradient centrifugation( DGC ) , smear cytologic examination( SCE) and pleural needle biopsy(PNB). Comparisons between these results and those of benign pleural effusions were also made. Results The positive rates of DGC, SCE and PNB for diagnosing MPEs were 94. 3 %, 62. 9% and 44.6%, respectively, and the positive rate of SCE combined with PNB for diagnosing MPEs was 73.2%. The positive rate of the exfoliative tumor cells ( ETCs ) by DGC was much higher than that of SCE or^and PNB with no false-positive. Conclusion The ETCs isolated by DGC from the MPEs is quite specific for the diagnosis of malignant tumors with higher sensitivity and practicality in clinico-patho-logical practice.
出处 《Journal of Shanghai Second Medical University(Foreign Language Edition)》 2004年第2期118-120,共3页 上海第二医科大学学报(英文版)
关键词 pleural effusion density gradient centrifugation exfoliative cells cytologic examination 诊断 倾斜度 表皮脱落 肿瘤细胞 恶性渗出物 胸膜 细胞学诊断 密度倾斜离心法
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