摘要
目的:分离和鉴定阿奇霉素中的相关物质。方法:运用色谱学和波谱学方法分离鉴定阿奇霉素中的相关物质。结果:从阿奇霉素中分离得到4个相关物质,鉴定了其中2个主要相关物质的结构分别为9-脱氧-9α'-氮杂-9α'-甲基-9α'-红霉素A和9-脱氧-9α-氮杂-9α-甲基-3'-氮缺甲基-9α-红霉素A。结论:4个相关物质均为首次从阿奇霉素粗品中分离得到的新化合物,但其中2个有待进一步鉴定。
Objective:To separate and identify related impurities of azithromycin. Methods:Chromatographic and spectroscopic methods were used to isolate and identify the related substances in azithromycin. Results: Four related impurities which were isolated from azithromycin are new products and two of them was identified preliminarily as 9- deoxo -9α' - aza - 9α' - methyl -9α'- homoerythromycin A and 9 - deoxo - 9α- aza -9α- methyl -3' - N -demethyl -9α -homoerythromycin A. Conclusion:The four related substances were obtained from azithromycin for the first time,but it is necessary to be further purified and identified for two other related impurities.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2004年第6期580-584,共5页
Chinese Journal of Pharmaceutical Analysis
