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高效液相色谱法测定乐舒凡口服液中盐酸氨溴索的含量 被引量:2

HPLC Determination of Content of Ambroxol Hydrochloride in Oral Solution of Losolven
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摘要 目的:建立盐酸氨溴索的HPLC含量测定方法。方法:色谱柱为C18柱,检测波长为245 nm。结果:在0.03-0.33 mg· mL-1浓度范围内呈良好线性关系,平均回收率为100.9%。结论:该法专属性强,操作简便,结果准确。 Objective:To develop an HPLC method for assay of ambroxol hydrochloride. Method: With a C18 analytical column,the mobile phase consisted of methanol -0. 02 mol·L-1 potassium dihydrogen phosphate(50: 50) ,and UV detector at 245 nm. Results: Under the condition, there was a good linear relationship in the concentration range of 0.03 -0.3 mg·mL-1 ,the average recovery was 100.9%. Concisions: The method is simple and accurate.
出处 《药物分析杂志》 CAS CSCD 北大核心 2004年第6期629-631,共3页 Chinese Journal of Pharmaceutical Analysis
关键词 高效液相色谱法 测定 乐舒凡口服液 盐酸氨溴索 含量 HPLC, ambroxol hydrochloride
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参考文献1

  • 1standard of Losolven Solution(乐舒凡口服液质量标准).Cansdian Pharmaceutical Laboratories(pacifie) Ltd (全福化学股分有限公司)1999.1

同被引文献18

  • 1成海平.药品研发中防腐剂的应用及质控[J].中国新药杂志,2005,14(8):954-956. 被引量:33
  • 2崔福德.药剂学[M].第7版.北京:人民卫生出版社,2011:296.
  • 3BIDian-zbou(毕殿洲).Phammceutics(药剂学).4thVersion(第四版).北京.人民卫生出版社,1999.199.
  • 4ZHENGCe(郑策)关注制剂中辅料的不良反应.医学继续教育,2006,20(28):10.
  • 5Satinsky D, Huclov6 J, Ferreira RL, et al. Determination of ambroxol hydrochloride, methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column. J Pharm Biomed Anal,2006,40 ( 2 ) :287.
  • 6Heinnen M, Barbas C. Validation of an HPLC method for the quan- tification of ambroxol hydrochloride and benzoic acid in a syrup as pharmaceutical form stress test for stability evaluation. J Pharm Bi- omed Anal,2001,24 ( 5 - 6) : 1005.
  • 7Koundourellis JE, Malliou ET, Broussali TA. High performance liq- uid chromatographic determination of ambroxol in the presence of different preservatives in pharmaceutical formulations , 2000,23 ( 2 -3) :469.
  • 8中国药典.2010.Vol1I(二部):附录IK.
  • 9SATíNSKY D, HUCLOVá J, FERREIRA R L, et al. Determination of ambroxol hydrochloride methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column [J]. J Pharm Biomed Anal, 2006, 40(2): 287-293.
  • 10HEIN?NEN M, BARBAS C. Validation of an HPLC method for the quantification of ambroxol hydrochloride and benzoic acid in a syrup as pharmaceutical form stress test for stability evaluation [J]. J Pharm Biomed Anal, 2001, 24(5/6): 1005-1010.

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