摘要
目的 探讨子宫颈淋巴瘤样病变的临床病理特征及鉴别诊断要点。方法 收集 6例子宫颈淋巴瘤样病变 ,观察其临床病理特点 ,进行免疫组化染色及随访。结果 6例平均年龄 4 7岁 ,临床表现不规则阴道出血 ,妇检示宫颈重度糜烂或息肉。镜检示致密的大淋巴细胞与多量成熟的小淋巴细胞、浆细胞以及分叶核白细胞混合存在 ,核分裂象活跃。免疫组化染色显示淋巴组织为多克隆性增生 ,大淋巴细胞CD30和CD2 0呈不同程度的阳性表达。结论 子宫颈淋巴瘤样病变是一种反应性淋巴组织增生性病变 ,需要注意与恶性淋巴瘤鉴别。病变特有的组织学表现及免疫组化染色有助于鉴别诊断。
Purpose To discuss the clinical and pathological features of the uterine cervical lymphoma like lesion and to analyze the main points of differential diagnosis. Methods Six cases of cervical lymphoma like lesion were studied by histological and immunohistochemical techniques, and their therapeutic results were followed up. Results The average age was 47 years. All of them had irregular vaginal hemorrhage, and serious cervix erosion or polypus. Microscopical examination showed dense infiltration of large lymphocyte with mitosis activity, mixed with mature small lymphocyte, plasmacyte and multilobe nucleared leucocyte. The immunohistochemical results indicated that the lymphatic tissue was polyclonal proliferation, the large lymphocytes were positive for CD30 and CD20. Conclusions Cervical lymphoma like lesion is a kind of reactive lymphoproliferative disease,it should be differentiated from malignant lymphoma. The typical histological image and immunohistochemical staining are helpful to differential diagnosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
2003年第2期132-134,共3页
Chinese Journal of Clinical and Experimental Pathology
