摘要
用ABC免疫组化法和LCA,UCHL_1,L_(26),Mac_(387),k,(?),EMA,CK和CEA等9种抗体标记了81例病理学不能确诊或分类的淋巴瘤样疾病。所有组织均用10%福尔马林固定,石蜡包埋,6μm切片。标记结果:3例确诊为未分化癌,72例为非何杰金淋巴瘤(NHL),5例为淋巴组织反应性增生,1例不能确诊。在72例NHL中,B细胞淋巴瘤49例,T细胞淋巴瘤19例,B、T细胞混合性淋巴瘤1例,组织细胞肉瘤3例。结果表明,应用可以标志石蜡切片中淋巴细胞抗原的LCA,UCHL_1,L_(26),Mac_(387)等单克隆抗体对于NHL的诊断和分型是有效的。如能应用1种以上的同类血清,结合其组织形态,可以进一步提高其诊断水平。
Nine antibodies,LCA,UCHL_1,L_(26),Mac_(387),K,(?),CK,EMA and CEA were assessed fortheir reactivity by labelling 81 cases of diagnosed as lymphomatoid disorders in formalin-fixed,paraf-fin embedded sections.The results of immunohistochemical staining were 3 cases of undifferentiatedcarcinomas,72 cases of non-Hodgkin's lymphomas(NHL),5 cases of lympho-tissue reactive hyper-plasia,and 1 case was undetermined diagnosis.In the 72 cases of NHL,B cell lymphomas were 49cases,T cell lymphornas 19 cases,B and T cell mixed type 1 case,and histocytic lymphomas 3 cases.We concluded that the monoclonal antibodied LCA,UCHL_1,L_(26),Mac_(387)are suitable for routine im- ??munostaing of conventionally fixed and processed blocks in diagnosing of the untypical case of malig-nant lymphomas.As 2 or more antibodies of the same kind are used,further useful diagnostic infor-mation will be given in most of the cases.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1993年第3期179-182,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
淋巴瘤
免疫组织化学
单克隆抗体
non-Hodgkin's lymphomas
immunohistochemistry
monoclonal antibody
differential diagnosis
